The CAR target is a neo-antigen present on the cell surface of more than 90% of ovarian cancer cells. T cells or NK cells with this CAR will seek and bind to ovarian cancer cells via the CAR and signal the immune cell to kill these dangerous cells. Cartherics is also researching how to use […]
Cartherics has an autologous CAR-T product treating ovarian cancer, entering clinical trials in 2024-25. The lead allogeneic product is expected to enter clinical trials for ovarian cancer in 2025. There is a pipeline of additional products focused on solid tumours following close behind. The Cartherics platform is expected to bring significant options for effective therapy […]
The Cartherics allogeneic (off-the-shelf) technology is based on umbilical cord blood cells from rare histocompatible donors that are converted to stem cells (iPSCs) and gene edited to introduce CARs and to knock-out genes that inhibit immune function. These are then converted into CAR-T or CAR-NK cells to enhance the patients’ own immune system to combat […]
Chimeric antigen receptors (CARs) are antibody fragments linked to activation molecules, that recognise molecules specifically present on the surface of cancer cells. These CAR complexes are genetically engineered into the immune cell (T cell or NK cell) genome and expressed on their surface. When the antibody fragment engages with the cancer cell, the activation molecules […]
Cartherics is a biotechnology company focused on developing innovative cancer therapies. We have developed immune killer cells (NK Cells) that are genetically modified and expanded for their therapy for solid tumours (ovarian and gastric cancers). Our primary focus is on therapies that involve gene editing stem cells made from donor umbilical cord blood and the […]
Cartherics’ mission is the development of novel, “off-the-shelf” (allogeneic) immune cell therapy products for the treatment of cancer.
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