11 March 2021

Cartherics is pleased to announce that on 8 March 2021 a review paper was approved for production and accepted for publication in the journal Frontiers in Genetics, section Cancer Genetics.

Titled: A role for integrin-linked kinase in colorectal cancer growth and progression via regulating senescence and immunity, the paper is a collaboration between Cartherics, Hudson Institute for Medical Research and Monash University.

Summary: Integrin-linked kinase (ILK) has been implicated as a molecular driver and mediator in both inflammation and tumorigenesis of the colon. ILK functions as an adaptor and mediator protein linking the extracellular matrix with downstream signalling.

This review discusses the possible role for ILK in senescence and immunity, paying particular attention to its relevance in colorectal cancer. It also examines how activating Toll-like receptors (TLRs) and their agonists in CRC could trigger immune responses against cancer, as a combination therapy with ILK inhibition.

Authors: Bryan Williams, Saleh Almasabi, Afsar U Ahmed and Richard Boyd.

Once the paper is published details will be posted on Cartherics’ website.