Cartherics CRC-P PhD and Honours Programs

Cartherics Pty Ltd is a recipient of  a prestigious Cooperative Research Centres (CRC) Project Grant entitled “Allogeneic Stem Cell Cancer lmmunotherapies”.

Cartherics and its CRC-P partners, which include Mesoblast Ltd, Cell Therapies Pty Ltd, Monash University and the Hudson Institute of Medical Research, are developing ‘off-the-shelf’ immunotherapy products for cancer using novel, specially selected, cell lines to create haplotype induced pluripotent stem cells (iPSCs) that can be infinitely expanded. These iPSCs will be gene edited and differentiated to become cytotoxic T cells as well as NK cells, with multiple targeting receptors for use in clinical trials, initially, for treatment of relapsed ovarian and gastric cancers.

The Cartherics team is closely aligned with leading cancer research groups, including The Peter Maccallum Cancer Centre and their partners at the new Victorian Comprehensive Cancer Centre and The Epworth Medical Centre, together with a strong research base at the Hudson Institute for Medical Research and Monash University and its affiliated clinical institutes of Monash Health.

As part of the CRC-P Program, Cartherics is offering high calibre, eligible, students PhD research programs of study that include world-class research training, as well as opportunities to develop diverse skills that will benefit their future career. The Cartherics PhD Program centres on medical research specifically combining stem cells and immunotherapy to cure cancer.

Research and training are based at the Monash Health Translation Precinct (MHTP) Translational Research Facility, a partnership of Monash University, the Hudson Institute of Medical Research and Monash Health. The Cartherics offices and laboratories are located on Level 7 of The Monash Health Translation Precinct Translational Research Facility.

Cartherics PhD Students are enrolled through Monash University into the prestigious Monash University Doctoral Program.

Cartherics Honours Degree Students can be enrolled through the Faculty of Science (BSc Hons Program), The Hudson Institute (B Med Sci Hons Program) or the Faculty of Medicine (Bachelor of Medical Science Hons Program).

Further information about the Monash University Graduate Research Program can be found at www.monash.edu/graduate-research

More specific information on the Faculty of Medicine, Nursing and Health Sciences Graduate Research Programs can be found at  https://www.monash.edu/medicine/research/grad-research

A brochure on the subject can be downloaded at https://www.monash.edu/__data/assets/pdf_file/0011/1470557/MNHS-Graduate-Research-Brochure.pdf

Please contact us for further information on any of the topics listed above.

Current Research Projects Available for 2021/2:

Projects include, but are not limited to:

The development of macrophages from iPSC (iMacs) for novel cancer immunotherapy.

Main Supervisor: Professor Alan Trounson
Co-supervisors: Dr Frederico Calhabeu, Professor Richard Boyd

Download project

The development of eosinophils from iPSC (iEos) for novel cancer immunotherapy.

Main Supervisor: Professor Alan Trounson
Co-supervisors: Dr Frederico Calhabeu, Professor Richard Boyd

Download project

Trophoblast: the new player in Regenerative Immunology

Main Supervisor: Professor Alan Trounson
Co-supervisors: Professor Richard Boyd, Dr Peter Hudson, Professor Graham Jenkin

Download project

Examples of Research Projects currently being undertaken by Cartherics PhD students:

1. Re-engineering the function of natural killer cell receptors via CRISPR/Cas9: a new approach for ‘off-the-shelf’ immunotherapy.

Supervisors: Professor Alan Trounson
Co-supervisor: Professor Richard Boyd, Dr Vera Evtimov, Dr Nicholas Boyd, Dr Roland Shu

Download project

2. Translating Chimeric Antigen Receptor into Cutaneous T cell Lymphoma

Supervisor: Professor Alan Trounson
Co-supervisor: Professor Richard Boyd, Dr Vera Evtimov

Download project

3. Developing a clinically translatable iPSC-derived immunotherapy

Supervisor: Professor Alan Trounson
Co-supervisor: Professor Richard Boyd, Dr Nicholas Boyd, Dr Vera Evtimov

Download project

4. In vivo rejuvenation of both cancer specific and generic T cell immunity by genetically edited iPSC derived common lymphoid progenitor cells. (Commercial in Confidence, for further information on this project please contact Professor Alan Trounson)

Supervisor: Professor Alan Trounson
Co-supervisor: Professor Richard Boyd, Dr Walid Azar

5. The role of integrin linked kinase in senescence and immunosuppressive tumor microenvironment in colon cancer

Supervisor: Professor Bryan Williams
Co-supervisor: Dr Afsar Ahmed, Professor Richard Boyd

Download project

How to Apply

Enquiries from high calibre, eligible candidates, including those already enrolled in a PhD Program, are welcome at any time. Prospective students should explore the research project links above. Contact the Project Supervisors to discuss your interest before applying. You and your supervisor will then need to complete an Expression of Interest form, if you are not already enrolled at Monash for a PhD.

Our Education Officer is available to advise and assist students with their application. International students may also choose to apply to the Institute for general consideration through Monash Connect at www.monash.edu/study/student-life/services-for-students/international-students . Scholarships PhD candidature can be applied for at any time of the year. However, there are strict University Scholarship application deadlines. Applications for domestic Scholarships close on 31st May and 31st October each year for mid-year and end of year applications, respectively. In some situations, Cartherics may agree to award interim funding for selected students, particularly those with a high likelihood of future scholarship success, until an external scholarship is obtained.

Domestic and international PhD students at Cartherics must have scholarship funding to support their PhD studies. All applications for admission and scholarships are made online once you have received an invitation to apply. Find out more on how to apply at www.monash.edu/graduate-research/future-students/apply.

We recognise that undertaking a PhD is a significant commitment. Therefore, eligible PhD students enrolled with Cartherics are also awarded a significant Cartherics top-up scholarship of up to AU$5,000 per annum for a maximum of 3.5 years to supplement their Monash Graduate Research Scholarship, as well as other incentives. This supplement is normally tax free.

Download Brochure

A useful guide for new PhD students in the link below :

A life guide for new PhD students

For further information contact

Graham Jenkin – Cartherics Education Officer
Professor, Department of Obstetrics and Gynaecology, Monash University
Scientific Director, Monash Health Translation Precinct Cell Therapies and Regenerative Medicine Platform

graham.jenkin@monash.edu

Mobile: +61 (0) 419 534 101

or

Karen Loudon – Executive Assistant

karen.loudon@hudson.org.au

+61 (3) 8572 2500